In Silico Analysis of Momordica charantia L. as Antidiabetic Agents of GSK-3β Receptors and It's Antioxidant Activity
DOI:
https://doi.org/10.23917/pharmacon.v22i2.13447Keywords:
Momordica charantia L.; GSK-3β Receptors; MetforminAbstract
-
Downloads
References
Afriana, D., & Dewi, C. (2022). Studi In Silico Senyawa Dari Saffron (Crocus sativus L.) Terhadap Reseptor Glikogen Sintase Kinase-3 Beta (GSK-3β) Sebagai Antidiabetes. Jurnal Pharmacia Mandala Waluya, 1(5), 188–201. https://doi.org/10.54883/jpmw.v1i5.
Abdullah, S. S., Antasionasti, I., Rundengan, G., & Abdullah, R. P. I. (2022). Aktivitas Antioksidan Ekstrak Etanol Biji dan Daging Buah Pala dengan (Myristica fragrans) Metode DPPH. Chemistry Progress, 15(2), 70–75. https://doi.org/10.35799/cp.15.2.2022.4448.
Andriani, D., & Murtisiwi, L. (2020). Uji Aktivitas Antioksidan Ekstrak Etanol 70% Bunga Telang (Clitoria ternatea L) dari Daerah Sleman dengan Metode DPPH. Pharmacon: Jurnal Farmasi Indonesia, 17(1), 70–76. https://doi.org/10.23917/pharmacon.v17i1.9321.
Achmad, A., Regar, D. N., & Harwoko. (2016). Efektivitas Ekstrak Buah Pare (Momordica charantia) dan Buncis (Phaseolus vulgaris) untuk Penurunan Kadar Gula Darah dan AUC (Area Under Curve). Pharmaceutical Journal of Indonesia, 2(1), 25–29. https://doi.org/10.21776/ub.pji.2016.002.01.5
Alkhalidy, H., Moore, W., Wang, A., Luo, J., McMillan, R. P., Wang, Y., Zhen, W., Hulver, M. W., & Liu, D. (2018). Kaempferol ameliorates hyperglycemia through suppressing hepatic gluconeogenesis and enhancing hepatic insulin sensitivity in diet-induced obese mice. J Nutr Biochem, 58, 90–101. https://doi.org/10.1002/hep.30150.Ductular
Awaluddin, A., Aksa, R., & Septiani, H. R. (2018). Studi Potensi Interaksi Farmakodinamik Metformin dan Ekstrak Etanol Daun Kersen(Muntigia calabura L.) Terhadap Perubahan KAdar Glukosa Darah pada Tikus. Farbal, 6(2), 44–49.
Akmal, T., & Sasongko, L. (2023). INFLUENCE OF Momordica charantia (L.) ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF GLICLAZIDE IN ALLOXAN-INDUCED DIABETIC RATS. Medical Sains : Jurnal Ilmiah Kefarmasian, 8(3), 1079–1088. https://doi.org/10.37874/ms.v8i3.854
Bakare, R. I., Magbagbeola, O. A., Akinwande, A. I., & Okunowo, O. W. (2010). Nutritional and chemical evaluation of Momordica charantia. Journal of Medicinal Plants Research, 4(21), 2189–2193.
B
ahagia, W., Kurniawaty, E., & Mustafa, S. (2018). Potensi Ekstrak Buah Pare (Momordhica charantia) Sebagai Penurun Kadar Glukosa Darah: Manfaat di Balik Rasa Pahit. Majority, 7(2), 177–181.
Bai, C., Wu, L., Li, R., Cao, Y., He, S., & Bo, X. (2025). Machine Learning-Enabled Drug-Induced Toxicity Prediction. Advanced Science, 2413405. https://doi.org/10.1002/advs.202413405
Bitew, M., Desalegn, T., Demissie, T. B., Belayneh, A., Endale, M., & Eswaramoorthy, R. (2021). Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study. PLoS ONE, 16(12). https://doi.org/10.1371/journal.pone.0260853
Effendi, N., Saputri, N. airin, Purnomo, H., & Aminah. (2023). ADME-T dan. Media Farmasi, 19(1), 10.
Fauziyyah, R. S., Huang, S. A., Sholehah, A. M., Dewi, T. T., Wulandari, R. P., Nurdin, H. A., & Nuwarda, F. (2025). In Silico Study of Secondary Metabolite Compound from Noni fruit ( Morinda citrifolia ) as Potential Drug Candidates for Type 2 Diabetes Mellitus Targeting PPAR- γ. Indonesian Journal of Chemical Science, 14(1).
Findrayani et., al. (2024). Studi Molecular Docking Senyawa Kimia dari Herba Putri Malu (Mimosa pudica) Terhadap Inhibisi Enzim A-Glukosidase Sebagai Antidiabetes Melitus. Jurnal Pharmacia Mandala Waluya, 3(4), 225–233. https://doi.org/10.54883/jpmw.v3i4.104.
IDF. (2021). IDF Diabetes Atlas 10 TH Edision. Internasional Diabetes Federation.
Ino Ischak, N., Musa, W. J., Ode Aman, L., Alio, L., La Kilo, A., & Deltalia Saleh, S. (2023). Studi Molecular Docking dan Prediksi ADME Senyawa Metabolit Sekunder Tumbuhan Obat Tradisional Gorontalo terhadap Reseptor HER-2 sebagai Antikanker Payudara. Jamb.J.Chem, 5(1), 90–103. https://www.rcsb.org/
Mahmoud, M. F., Hassan, N. A., El Bassossy, H. M., & Fahmy, A. (2013). Quercetin Protects against Diabetes-Induced Exaggerated Vasoconstriction in Rats: Effect on Low Grade Inflammation. PLoS ONE, 8(5). https://doi.org/10.1371/journal.pone.0063784
Mailandari, M. (2012). Uji Aktivitas Antioksidan Ekstrak Daun Garcinia kydia Roxb. Dengan metode DPPH dan IdentfikasiSenyawa Kimia Fraksi Yang Aktif. Fakultas Matematika Dan Ilmu Pengetahuan Alam Program Studi Ekstensi Farmasi. Universitas Indonesia, 13.
Nirnadia, N., Kamilla, L., & Djohan, H. (2020). Potensi Pare (Momordica Charantia Linn) Sebagai Antidiabetes. Jurnal Laboratorium Khatulistiwa, 4(1), 34. https://doi.org/10.30602/jlk.v4i1.942
Novianty, R. (2023). Innovation of Areca catechu Compounds Combined with Fluoxetine as Antidepressant by In Silico Method. Photon: Jurnal Sain Dan Kesehatan, 13(2), 70–77. https://doi.org/10.37859/jp.v13i2.5041.
Octariani, S., Mayasari, D., & Ramadhan, A. M. (2021). Optimasi Polivinilalkohol (PVA) Sebagai Basis Sediaan Gel Antijerawat. Proceeding of Mulawarman Pharmaceuticals Conferences, 135–138. http://prosiding.farmasi.unmul.ac.id/index.php/mpc/article/view/416/399
Oyelere, S. F., Ajayi, O. H., Ayoade, T. E., Pereira, G. B. S., Owoyemi, B. C. D., Ilesanmi, A. O., & Akinyemi, O. A. (2022). A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia. Heliyon, 8(4), e09253. https://doi.org/10.1016/j.heliyon.2022.e09253
Peng, J., Li, Q., Li, K., Zhu, L., Lin, X., Lin, X., Shen, Q., Li, G., & Xie, X. (2017). Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1. Journal of Diabetes Research, 2017. https://doi.org/10.1155/2017/3417306
Pramesthi, A. D. E. D. (2019). Drug-Herb Interaction between Metformin and Momordica Charantia in Diabetic Mice. Diabetes & Obesity International Journal, 4(3), 1–7. https://doi.org/10.23880/doij-16000203
Pramesthi, A. D. E. D., Lukitaningsih, E., & Nugroho, A. E. (2022). Potential Pharmacokinetics and Pharmacodynamics (PK-PD) Drug-Herbs Interactions (DHI) from Metformin and Traditional Medicines: A Literature Review. Pharmacognosy Journal, 14(1), 235–244. https://doi.org/10.5530/pj.2022.14.29
Ramadhani, R., Baruna, I., Vedha, G. B., & Lutfi Chabib. (2023). Kandungan Senyawa Sambiloto dan Jahe Terhadap Protein Target Covid-19 Menggunakan Docking Molekuler. Parapemikir : Jurnal Ilmiah Farmasi Vol, 12(2), 157–171.
Rajagopal, P. lakshmi. (2022). Molecular docking analysis of metformin analogues with GSK-3β. Bioinformation, 18(3), 269–272.https://doi.org/10.6026/97320630018269
Rantung, O., Korua, A. I., & Datau, H. (2021). Metode Spektrofotometer UV untuk Uji Vitamin C dalam Buah-Buahan. Prosiding, 61.
Richter, E., Geetha, T., Burnett, D., Broderick, T. L., & Babu, J. R. (2023). The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer’s Disease. International Journal of Molecular Sciences, 24(5). https://doi.org/10.3390/ijms24054643
Seal, S., Mahale, M., García-Ortegón, M., Joshi, C. K., Hosseini-Gerami, L., Beatson, A., Greenig, M., Shekhar, M., Patra, A., Weis, C., Mehrjou, A., Badré, A., Paisley, B., Lowe, R., Singh, S., Shah, F., Johannesson, B., Williams, D., Rouquie, D., … Bender, A. (2025). Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World. Chemical Research in Toxicology.https://doi.org/10.1021/acs.chemrestox.5c00033
Syafitri, A., & Mardatillah, H. F. (2022). Uji Efektivitas Antidiabetes Kombinasi Ekstrak Buah Pare (Momordica charantia L.) Dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Pada Tikus Jantan Putih Sebagai Hewan Percobaan. Jurnal Farmasi Dan Hernal, 4(2).
Scott, B., Day, E. A., O’Brien, K. L., Scanlan, J., Cromwell, G., Scannail, A. N., McDonnell, M. E., Finlay, D. K., & Lynch, L. (2024). Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans. Nature Metabolism, 6(4), 651–658. https://doi.org/10.1038/s42255-024-01018-7
Supringrum, R., & Jubaidah, S. (2019). AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAN FRAKSI AKAR TABAR KEDAYAN (Aristolochia foveolata Merr.) DENGAN METODE DPPH (2,2 DIPHENYL-1-PICRILHYDRAZIL). JFL : Jurnal Farmasi Lampung, 8–14. https://doi.org/10.37090/jfl.v8i1.81
Wu, M., Xu, H., Liu, J., Tan, X., Wan, S., Guo, M., Long, Y., & Xu, Y. (2021). Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms. Journal of Diabetes Research, 2021. https://doi.org/10.1155/2021/6673525
World Health Organization (WHO). (2021). International Classification of Diseases(ICD-11). Geneva: World Health Organization.
Xu, B., Li, Z., Zeng, T., Zhan, J., Wang, S., Ho, C. T., & Li, S. (2022). Bioactives of Momordica charantia as Potential Anti-Diabetic/Hypoglycemic Agents. Molecules, 27(7), 1–17. https://doi.org/10.3390/molecules27072175
