Profile of Crude Drugs Quality and Chemical Contents of a Masuk angin Polyherbal Formulation from Baturraden
DOI:
https://doi.org/10.23917/pharmacon.v23i1.8113Keywords:
Curcuminoids, ethyl-p-methoxy cinnamate, Herbal raw materials, Jamu, Quality profile, StandardizationAbstract
The Baturraden people utilize a polyherbal formulation composed of red ginger rhizomes, turmeric rhizomes, aromatic ginger rhizomes, and rice starches to alleviate masuk angin. This study aims to evaluate the quality profile of crude drugs of red ginger, turmeric, and aromatic ginger as well as to assess the effect of the weight ratio of the crude drugs toward the total curcuminoid and ethyl p-methoxycinnamate (EPMC) contents of the formulations containing those crude drug extracts. Crude drug quality characterization followed parameters and standards specified in the Indonesian Herbal Pharmacopoeia (IHP). The crude drugs were individually extracted using ethanol, and the resulting extracts were combined into seven formulations with varying weight ratios. Total curcuminoid and EPMC contents in the formulations were determined using the UV-Vis spectrophotometry and thin-layer chromatography (TLC)-densitometry methods, respectively. The turmeric crude drugs exhibited good quality profiles. The red ginger crude drugs met quality standards except for acid-insoluble ash and water-extractable parameters, while the aromatic ginger ones did not meet the essential oil content standard. Different weight ratios of red ginger, turmeric, and aromatic ginger extracts resulted in formulations with varying total curcuminoid and EPMC contents. Formula 4 that contains an equal weight ratio of red ginger, turmeric, and aromatic ginger crude drugs and exhibits a considerably high total curcuminoid (8.08±1.31%) and EPMC (4.43±0.33%) content among other formulations.
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