The Quality of Life Breast Cancer Patients Receiving Chemotherapy and The Factors Affecting It in a Regional Hospital in Gianyar
DOI:
https://doi.org/10.23917/pharmacon.v21i2.6914Keywords:
Breast cancer, chemotherapy, patients characteristics, quality of lifeAbstract
The effects of breast cancer and chemotherapy can impact the quality of life (QOL) of patients. However, QOL can also be influenced by various characteristics directly related to them. This study aimed to analyze the QOL of breast cancer patients undergoing chemotherapy and the factors that can affect it. It was cross-sectional study conducted at a hospital in Gianyar, Bali in May-June 2024, with a sample of 135 breast cancer patients undergoing chemotherapy, selected using the purposive sampling method. The inclusion criteria required patients to have complete medical records and to agree to participate in the study, while those who did not fully complete the questionnaire were excluded. The research instrument used the EORTC QLQ C-30 and EORTC QLQ BR-23 questionnaires to assess QOL, as well as data collection sheets for personal and clinical information. Data were analyzed using Spearman's rho test, Eta test, and Mann-Whitney U-test, (CI 95%). Findings showed the majority of the respondents were <60 years old (84.4%), female (100.0%), had completed elementary school (46.7%), were employed (56.2%), lived far from health facilities (75.6%), had stage 2 cancer (48.1%), received treatment >3 times per month (51.9%), had no comorbidities (96.3%), underwent a combination of injection and oral chemotherapy (37.8%), and had an average QOL score of 93.2±8.9. Type of chemotherapy and comorbidities correlated with the QOL of the patients (p<0.001), while sociodemographic characteristics did not. Positive support from health workers, family, and the patient's environment was suspected to contribute to a good QOL.
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Abotaleb. M., Kubatka, P., Caprnda, M., et al. (2018). Chemotherapeutic agents for the treatment of metastatic breast cancer: Biomed Pharmacother, 101, 458-477. https://doi.org/10.1016/j.biopha.2018.02.108 DOI: https://doi.org/10.1016/j.biopha.2018.02.108
Adli, M., Shatri, H., Sutdanyo, N., & Suwarto, S. (2020). Validity and Reliability Test of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Breast 23 in Breast Cancer Patient on Treatment. J. Penyakit Dalam Indones, 7(4), 229-234. https://doi.org/10.7454/jpdi.v7i4.526 DOI: https://doi.org/10.7454/jpdi.v7i4.526
Afifah, V.A., & Sarwoko, S. (2020). Faktor-Faktor Yang Mempengaruhi Kualitas Hidup Pasien Kanker Payudara Yang Menjalani Kemoterapi. J. Komun. Kesehatan, 11(1), 106-119. https://doi.org/10.56772/jkk.v11i1.165
Aisyah, N., Syarifuddin, A., Amami, P., & Mardiana, M. (2020). Analisis Biaya Kemoterapi Pasien Kanker Payudara Dan Kanker Serviks Di RSUD Ulin Banjarmasin. J Insan Farm Indones. 2020;3(1):19–28. https://doi.org/10.36387/jifi.v3i1.500 DOI: https://doi.org/10.36387/jifi.v3i1.500
Ambarwati, W.N., & Wardani, E.K. (2014). Efek Samping Kemoterapi Secara Fisik Pasien Penderita Kanker Serviks. Prosiding Seminar Nasional dan Internasional (pp. 97-106). Semarang: Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Muhammadiyah Semarang. Available on https://jurnal.unimus.ac.id/index.php/psn12012010/article/view/1428
American Cancer Society. (2021). Chemotherapy for Breast Cancer. Available from: https://www.cancer.org/cancer/types/breast-cancer/treatment/chemotherapy-for-breast-cancer.html
Anggreni, R., Zukhra, R.M., & Elita, V. (2022). Gambaran Kualitas Hidup Pasien Kanker Payudara: Literature Review. J. Online Mhs. JOM Bid. Ilmu Keperawatan, 9(1), 76–85. https://doi.org/10.48144/prosiding.v1i.708
Aprilianto, E., Lumadi, S.A., & Handian, F.I. (2021). Family social support and the self-esteem of breast cancer patients undergoing neoadjuvant chemotherapy. J Public Health Res., 10(2), 2234. https://doi.org/10.4081/jphr.2021.2234 DOI: https://doi.org/10.4081/jphr.2021.2234
Astarini, M.I.A., Lilyana, M.T.A., & Prabasari, N.A. (2020). Perspektif Perawat Ruangan tentang Caring dalam Merawat Pasien Kanker yang Menjalani Kemoterapi. JKEP, 5(2), 171–184. https://doi.org/10.32668/jkep.v5i2.389 DOI: https://doi.org/10.32668/jkep.v5i2.389
Barrios, C.H. (2022). Global challenges in breast cancer detection and treatment. Breast, 62 Suppl 1(Suppl 1), S3-S6. https://doi.org/10.1016/j.breast.2022.02.003 DOI: https://doi.org/10.1016/j.breast.2022.02.003
Cardoso, F., Colleoni, M., Di Leo, A., Francia, G., et al. (2016). Oral chemotherapy in advanced breast cancer: expert perspectives on its role in clinical practice. Cancer Treat. Commun, 6(Supp.1), S1–S10. https://doi.org/10.1016/S2213-0896(16)06001-1 DOI: https://doi.org/10.1016/S2213-0896(16)06001-1
Chen, Q., Li, S., Wang, M., Liu, L., & Chen, G. (2018). Health-Related Quality of Life among Women Breast Cancer Patients in Eastern China. Biomed Res Int., 2018, 1452635. https://doi.org/10.1155/2018/1452635 DOI: https://doi.org/10.1155/2018/1452635
Dinkes Denpasar. (2022). Profil Dinas Kesehatan Kota Depasar Tahun 2022. Dinas Kesehatan Kota Denpasar. Available on https://drive.google.com/file/d/1ybRXajS7ybj2HniD0RgiCGGTyG8y-CUG/view
EORTCa. (2024). EORTC QLQ-C30. The European Organization for the Research and Treatment of Cancer. Available from: https://qol.eortc.org/questionnaire/eortc-qlq-c30/
EORTCb. (2024). EORTC QLQ-BR23. The European Organization for the Research and Treatment of Cancer. Available from: https://qol.eortc.org/questionnaire/update-qlq-br23/
EORTCc. (2024). Scoring Manual. The European Organization for the Research and Treatment of Cancer. Available from: https://qol.eortc.org/manuals/
EORTCd. (2024). EORTC QLQ BR-42. The European Organization for the Research and Treatment of Cancer. Available from: https://qol.eortc.org/questionnaire/update-qlq-br23/
Epstein, R.S., Basu Roy, U.K., Aapro, M., et al. (2021). Cancer Patients' Perspectives and Experiences of Chemotherapy-Induced Myelosuppression and Its Impact on Daily Life. Patient Prefer Adherence, 15:453-465. https://doi.org/10.2147/PPA.S292462 DOI: https://doi.org/10.2147/PPA.S292462
Fitriani, L., Nur, A.A., Jinan, R., Selyiana, R.E., Rahman, F., & Laily, N. (2021). Keputusan Pemilihan Pelayanan Pengobatan Ditinjau dari Karakteristik Individu dan Aksesibilitas. JPPKMI, 2, 67–75. https://doi.org/10.15294/jppkmi.v2i1.47366 DOI: https://doi.org/10.15294/jppkmi.v2i1.47366
Ganesh, S., Lye, M.S., & Lau, F.N. (2016). Quality of Life among Breast Cancer Patients in Malaysia. Asian Pac J Cancer Prev, 17(4), 1677-1684. https://doi.org/10.7314/apjcp.2016.17.4.1677 DOI: https://doi.org/10.7314/APJCP.2016.17.4.1677
Globocan. (2020). New Global Cancer Data. World Health Organization. Available from: https://www.uicc.org/news/globocan-2020-new-global-cancer-data
Gregorowitsch, M.L., Ghedri, A., Young-Afat, D.A., et al. (2019). The effect of chemotherapy on subjective cognitive function in younger early-stage breast cancer survivors treated with chemotherapy compared to older patients. Breast Cancer Res Treat., 175(2), 429-441. https://doi.org/10.1007/s10549-019-05149-4 DOI: https://doi.org/10.1007/s10549-019-05149-4
Habib, M.B., Hanafi, I., Al Zoubi, M., Bdeir, Z., & Yassin, M.A. (2021). Severe and Late Acute Liver Injury Induced by Capecitabine. Cureus, 13(1), e12477. https://doi.org/10.7759/cureus.12477 DOI: https://doi.org/10.7759/cureus.12477
Husni, M., Romadoni, S., & Rukiyati, D. (2015). Hubungan Dukungan Keluarga dengan Kualitas Hidup Pasien Kanker Payudara di Instalasi Rawat Inap Bedah RSUP Dr. Mohammad Hoesin Palembang Tahun 2012. J. Keperawatan Sriwij, 2(2), 77–83. Available on https://media.neliti.com/media/publications/181743-ID-hubungan-dukungan-keluarga-dengan-kualit.pdf
Iqmy, L., Setiawati, S., & Yanti, D. (2021). Faktor Risiko yang Berhubungan dengan Kanker Payudara. JKM (Jurnal Kebidanan Malahayati), 7(1), 32-36. https://doi.org/10.33024/jkm.v7i1.3581 DOI: https://doi.org/10.33024/jkm.v7i1.3581
Irawan, E., Al Fatih, H., & Faishal, F. (2021). Faktor Faktor Yang Mempengaruhi Kualitas Hidup Pasien Diabetes Mellitus Tipe II di Puskesmas Babakan Sari. J. Keperawatan BSI, 9(1), 74–81. https://ejurnal.ars.ac.id/index.php/keperawatan/article/view/483
Johnson, R.H., Anders, C.K., Litton, J.K., Ruddy, K.J., & Bleyer, A. (2018). Breast cancer in adolescents and young adults. Pediatr Blood Cancer, 65(12), e27397. https://doi.org/10.1002/pbc.27397 DOI: https://doi.org/10.1002/pbc.27397
Juwita, D.A., Almahdy, A., & Afdhila, R. (2018). Pengaruh Karakteristik Pasien Terhadap Kualitas Hidup Terkait Kesehatan Pada Pasien Kanker Payudara di RSUP Dr.M. Djamil Padang, Indonesia. JSFK J. Sains Farm. Klin., 5(2), 126–133. https://doi.org/10.25077/jsfk.5.2.126-133.2018 DOI: https://doi.org/10.25077/jsfk.5.2.126-133.2018
Kulkarni, P.Y., & Velhal, G. (2023). Low Emotional Intelligence: A Precursor of Mental Health Derangements Among Adolescents. Cureus, 15(10), e46321. https://doi.org/10.7759/cureus.46321 DOI: https://doi.org/10.7759/cureus.46321
Larasati, A.D., Nugroho, A.F., & Tei, M.M. (2020). Self Care Management Activities to Improve Psychological Serenity of Cancer Patients. J. Keperawatan Jiwa, 8(3), 337–352. https://doi.org/10.26714/jkj.8.3.2020.337-352 DOI: https://doi.org/10.26714/jkj.8.3.2020.337-352
Larasati, M.S.P., Setiawan, I.G.B., Wetan, N.G.A.A.M.Y., & Manuaba, I.B.T.W. (2021). Faktor-Faktor yang Memengaruhi Kualitas Hidup Pasien Kanker Payudara Post Mastektomi di RSUP Sanglah. J Med Udayana, 11(10), 107-115. https://doi.or/10.24843.MU.2022.V11.i10.P18
Mahmuddin, M., Lestari, D.R., & Rizani, I. (2019). Hubungan Lama Menjalani Kemoterapi Dengan Kualitas Hidup Penderita Kanker Payudara Di RSUD Ulin Banjarmasin. Din. Kesehat. J., 10(1), 253–265. https://doi.org/10.33859/dksm.v10i1.455 DOI: https://doi.org/10.33859/dksm.v10i1.455
Marangyana, I.G.B.I., Nugraha, I.S., Mardyawati, I.A.K.S. (2022). Gambaran Peresepan Obat Kemoterapi Oral pada Pasien Kanker Payudara di RSUD Sanjiwani Gianyar. J Pharmactive, 1(1), 33-40. Available on http://download.garuda.kemdikbud.go.id/article.php?article=3401813&val=29861&title=GAMBARAN%20PERESEPAN%20OBAT%20KEMOTERAPI%20ORAL%20PADA%20PASIEN%20KANKER%20PAYUDARA%20DI%20RSUD%20SANJIWANI%20GIANYAR
Massardi, N.A. (2021). The Role of Estrogen in The Development of Breast Cancer. Biomed J of Ind., 7(2), 231-241. https://doi.org/10.32539/BJI.v7i2.280 DOI: https://doi.org/10.32539/bji.v7i2.280
Muralidharan, S., Gore, M., & Katkuri, S. (2023). Cancer care and economic burden-A narrative review. J Family Med Prim Care, 12(12), 3042-3047. https://doi.org/10.4103/jfmpc.jfmpc_1037_23 DOI: https://doi.org/10.4103/jfmpc.jfmpc_1037_23
Mursyid, A., Haris, R.N.H., Endarti, D., Wiedyaningsih, C., & Kristina, S.A. (2019). Pengukuran Kualitas Hidup Pasien Kanker Payudara di Kota Denpasar Menggunakan Instrumen EQ-5D-5L. JMPF, 9(3), 203-212. https://doi.org/10.22146/jmpf.47192 DOI: https://doi.org/10.22146/jmpf.47192
Nancy, N., Maysaroh, T., & Unggulian, H.G. (2023). Adult Cancer Patients’ Quality of Life After Outpatient Chemotherapy with JKN Coverage. J Jam Kes Nasional, 3(1), 130-142. https://doi.org/10.53756/jjkn.v3i1.144 DOI: https://doi.org/10.53756/jjkn.v3i1.144
Natasya, M. (2018). Gambaran Kualitas Hisup Pasien Kanker Payudara dengan Perawatan Paliatif oleh Garwita Institute. Jember: Skripsi, Fakultas Kesehatan Masyarakat, Universitas Jember. Available on https://repository.unej.ac.id/handle/123456789/86468
Nomiko, D. (2020). Faktor-Faktor yang Berhubungan dengan Kualitas Hidup Pasien Kanker Payudara di RSUD Raden Mattaher Jambi. J. Ilm. Univ. Batanghari Jambi, 20(3), 990–995. https://doi.org/10.33087/jiubj.v20i3.1089 DOI: https://doi.org/10.33087/jiubj.v20i3.1089
Marada, N, Hano, Y.H., Hafid, W. (2024). Hubungan Jarak Tempat Tinggal dan Pengetahuan Masyarakat Terhadap Pemanfaatan Pelayanan Puskesmas. J Kolaboratif Sains, 7(8), 3075-3080. https://doi.org/10.56338/jks.v7i8.5863
Paji, A., Kewuan, N., & Febriyanti, E. (2021). Hubungan antara Kemoterapi dengan Kualitas Hidup Penderita Kanker Payudara di RSUD Prof. Dr. W. Z. Johannes Kupang. CHMK Appl. Sci. J., 4(2), 99–103. https://doi.org/10.37792/casj.v4i2.1059
Perkumpulan PRAKARSA. (2023). Konsekuensi Finansial Pengobatan Kanker di Indonesia: Studi Kasus Penderita Kanker di Ibu Kota Jakarta. Jakarta, Perkumpulan PRAKARSA. Available on https://repository.theprakarsa.org/media/publications/563332-konsekuensi-finansial-pengobatan-kanker-2a792858.pdf
Perwitasari, D.A., Atthobari, J., Dwiprahasto, I., et al. (2011). Translation and validation of EORTC QLQ-C30 into Indonesian version for cancer patients in Indonesia. Jpn J Clin Oncol, 41(4), 519-529. https://doi.org/10.1093/jjco/hyq243 DOI: https://doi.org/10.1093/jjco/hyq243
Rahayu, S.M., & Suprapti, T. (2020). Kualitas Hidup Pasien Kanker yang Menjalani Kemoterapi di Bandung Cancer Sociaty. J. Wacana Kesehat., 5(2), 551-556. https://doi.org/10.52822/jwk.v5i2.148 DOI: https://doi.org/10.52822/jwk.v5i2.148
Rahmiwati, R., Yenni, Y., Adzkiya, M. (2022). Kualitas Hidup Pasien Kanker Payudara Berdasarkan Karakteristik Pasien Dan Dukungan Keluarga. Hum. Care J, 7(2), 281–289. https://doi.org/10.32883/hcj.v7i2.1557 DOI: https://doi.org/10.32883/hcj.v7i2.1557
Ratna, W., & Yuniarti, E. (2021). Kualitas Hidup Pasien Kanker Rawat Jalan yang Menjalani Kemoterapi di RSUD Kota Yogyakarta. Maj. Farm., 17(2), 278–286. https://doi.org/10.22146/farmaseutik.v17i2.62832 DOI: https://doi.org/10.22146/farmaseutik.v17i2.62832
Sari, S.L., Indra, R.L., & Lestari, R.F. (2019). Korelasi Persepsi Tentang Efek Samping Kemoterapi dengan Kualitas Hidup Pasien Kanker Payudara. J. Cakrawala Promkes, 1(2), 40–47. https://doi.org/10.12928/promkes.v1i2.1771 DOI: https://doi.org/10.12928/promkes.v1i2.1771
Sebastian, D., Joseph, J., & Mathews, E. (2023). The prevalence and correlates of comorbidities among patients with cancer attending a tertiary care cancer center in South India: An analytical cross-sectional study. Cancer Res Stat Treat, 6(4), 526-533. https://doi.org/10.4103/crst.crst_93_23 DOI: https://doi.org/10.4103/crst.crst_93_23
Sesrianty, V., Selsa, T., & Fradisa, L. (2021) Hubungan Dukungan Keluarga dengan Kualitas Hidup Pasien Kanker Payudara. J Kes Saintika Meditory, 6(2), 473-481. Available on https://jurnal.syedzasaintika.ac.id/index.php/meditory/article/view/2179
Shafaee, F.S., Mirghafourvand, M., Harischi,. S., Esfahani, A., & Amirzehni, J. (2018). Self-Confidence and Quality of Life in Women Undergoing Treatment for Breast Cancer. Asian Pac J Cancer Prev., 19(3), 733-740. https://doi.org/10.22034/APJCP.2018.19.3.733
Shinta, R.N., & Surarso, B. (2016). Terapi Mual Muntah Pasca Kemoterapi. J. THT, 9(2),74–83. Available on https://journal.unair.ac.id/download-fullpapers-thtklac6b53d6eefull.pdf
Sprague, B.L., Ahern, T.P., Herschorn, S.D., Sowden, M., Weaver, D.L., & Wood, M.E. (2021). Identifying key barriers to effective breast cancer control in rural settings. Prev Med, 152 (Pt 2), 106741. https://doi.org/10.1016/j.ypmed.2021.10674 DOI: https://doi.org/10.1016/j.ypmed.2021.106741
Subagya, A.N., Artanty, W., & Hapsari, E.D. (2018). Hubungan Harga Diri dengan Kualitas Hidup Wanita Menopause. J. Persat. Perawat Nas. Indonesia, 2(3), 177–193. https://doi.org/10.32419/jppni.v2i3.94 DOI: https://doi.org/10.32419/jppni.v2i3.94
Sudiasta, D.G., Yanti, N.L.G.P., & Citrawati, N.K. (2022). Overview of the Quality of Life of Breast Cancer Patients Undergoing Chemotherapy During the COVID-19 Pandemic. JKF, 4(2), 260-267. https://doi.org/10.35451/jkf.v4i2.986 DOI: https://doi.org/10.35451/jkf.v4i2.986
Tunas, I.K., Yowani, S.C., Indrayathi, P.A., Noviyani, R., & Budiana, I.N.G. (2016). Penilaian Kualitas Hidup Pasien Kanker Serviks dengan Kemoterapi Paklitaksel–Karboplatin di RSUP Sanglah. J. Farm. Klin. Indones., 5(1), 35–46. https://doi.org/10.15416/ijcp.2016.5.1.35
Üstündağ, S., & Zencirci, A.D. (2015). Factors affecting the quality of life of cancer patients undergoing chemotherapy: A questionnaire study. Asia Pac J Oncol Nurs, 2(1), 17-25. https://doi.org/10.4103/2347-5625.152402 DOI: https://doi.org/10.4103/2347-5625.152402
Wahyuni, F.A., Supadmi, W., & Yuniarti, E. (2020). Quality of life in cancer outpatients using the EORTC QLQ-C30 questionnaire at PKU Muhammadiyah Yogyakarta Hospital. Farmasains J. Farm. Dan Ilmu Kes. 5, 63–70. https://doi.org/10.22219/farmasains.v5i2.15219
Wang, T., Molassiotis, A., Chung, B.P.M., & Tan, J.Y. (2018). Unmet care needs of advanced cancer patients and their informal caregivers: a systematic review. BMC Palliat Care, 17, 96. https://doi.org/10.1186/s12904-018-0346-9 DOI: https://doi.org/10.1186/s12904-018-0346-9
WHO. (2024). Breast cancer. World Health Organization. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer
Wulandari, N., Bahar, H., & Ismail, C.S. (2017). Gambaran Kualitas Hidup Pada Penderita Kanker Payudara di Rumah Sakit Umum Bahteramas Provinsi Sulawesi Tenggara Tahun 2017. Jimkesmas Unsyiah., 2(6), 1-9. https://doi.org/10.37887/jimkesmas.v2i6.2879
