Antibacterial Activity of Ethyl Acetate Extract of Mango Bud (Mangifera indica L. var. Arum Manis) Against Multidrug-Resistant Bacteria
DOI:
https://doi.org/10.23917/pharmacon.v21i2.4697Keywords:
Mangifera indica L. var Arum Manis, ethyl acetate extract, antibacterial activity, multidrug-resistant bacteriariaAbstract
Ethyl acetate extracts of Mangifera indica leaves had chemical constituents such as saponins, alkaloids, phenols, tannins, flavonoids and diterpenes. Purified extract of Mangifera indica leaves had antibacterial activity against S. aureus and E. coli. This research aimed to know the antibacterial activity of mango bud (Mangifera indica L. var Arum Manis) against S. aureus, E. coli, P. aeruginosa and their multidrug resistant spesies. Arum manis mango bud simplicia powder was extracted by maceration method used ethyl acetate solvent. This extract tested to flavonoids and alkaloids by qualitative methods. Antibacterial activity used disc diffusion method and the concentration of this extract such as 10, 20, 30, 40 and 50%. Data of antibacterial activity was analyzed by descriptively. Arum manis mango bud extract had antibacterial activity against all of tested bacteria with diameter of zone of inhibition at 6.76 – 12.20 mm. The arum manis mango bud extract contained flavonoids and alkaloids.
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Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016). Methods for in vitro evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis, 6(2), 71–79. https://doi.org/10.1016/j.jpha.2015.11.005 DOI: https://doi.org/10.1016/j.jpha.2015.11.005
Cahyanto, T., Fadillah, A., Ulfa, R. A., Hasby, R. M., & Kinasih, I. (2020). Mangiferin Levels in Five Young Leaf Cultivar of Mango (Mangifera indica L.). Al-Kauniyah: Jurnal Biologi, 13(2), 242–249. https://doi.org/10.15408/kauniyah.v13i1.14810 DOI: https://doi.org/10.15408/kauniyah.v13i1.14810
Drewnowski, A. (2001). The Science and Complexity of Bitter Taste. Nutrition Reviews, 59(6), 163–169. https://doi.org/https://doi.org/10.1111/j.1753-4887.2001.tb07007.x DOI: https://doi.org/10.1111/j.1753-4887.2001.tb07007.x
Kanwal, Q., Husain, I., Siddiqui, H. L., & Javaid, A. (2010). Antifungal activity of flavonoids isolated from mango (Mangifera indica L.) leaves. Natural Products Research, 24(20). https://doi.org/https://doi.org/10.1080/14786419.2010.488628 DOI: https://doi.org/10.1080/14786419.2010.488628
Khan, H. A., Ahmad, A., & Mehboob, R. (2015). Nosocomial infections and their control strategies. Asian Pacific Journal of Tropical Biomedicine, 5(7), 509–514. https://doi.org/10.1016/j.apjtb.2015.05.001 DOI: https://doi.org/10.1016/j.apjtb.2015.05.001
Khandare, M. S. (2016). Mango (Mangifera indica Linn) A medicinal and holy plant. Journal of Medicinal Plants Studies, 4(4), 44–46. https://www.plantsjournal.com/archives/?year=2016&vol=4&issue=4&part=A&ArticleId=379
Kim, S. B., Bisson, J., Friesen, J. B., Pauli, G. F., & Charlotte, S. (2020). Selective Chlorophyll Removal Method to “Degreen” Botanical Extracts. J Nat Prod., 83(6), 1846–1858. https://doi.org/10.1021/acs.jnatprod.0c00005 DOI: https://doi.org/10.1021/acs.jnatprod.0c00005
Kumar, M., Saurabh, V., Tomar, M., Hasan, M., Changan, S., Sasi, M., Maheshwari, C., Prajapati, U., Singh, S., Prajapat, R. K., Dhumal, S., Punia, S., Amarowicz, R., & Mekhemar, M. (2021). Mango (Mangifera indica l.) leaves: Nutritional composition, phytochemical profile, and health-promoting bioactivities. Antioxidants, 10(2), 1–23. https://doi.org/10.3390/antiox10020299 DOI: https://doi.org/10.3390/antiox10020299
Laulloo, J. S., Bhowon, M. G., Soyfoo, S., & Chua, L. S. (2018). Nutritional and Biological Evaluation of Leaves of Mangifera indica from Mauritius. Journal of Chemistry, 2018. https://doi.org/10.1155/2018/6869294 DOI: https://doi.org/10.1155/2018/6869294
Ministry of Health of the Republic of Indonesia. (1986). Galenical Preparation. Jakarta, Direktorat Jenderal Pengawasan Obat dan Makanan.
Mulangsri, D. A. K., & Zulfa, E. (2020). Antibacterial Activity of Arumanis Mango Leaves (Mangifera indica L.) Purified Extract and Identification of Flavonoids by TLC. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 6(1), 55–62. https://doi.org/10.22487/j24428744.2020.v6.i1.14044 DOI: https://doi.org/10.22487/j24428744.2020.v6.i1.14044
Nimer, N. A. (2022). Nosocomial Infection and Antibiotic-Resistant Threat in the Middle East. Infection and Drug Resistance, 15(February), 631–639. https://doi.org/10.2147/IDR.S351755 DOI: https://doi.org/10.2147/IDR.S351755
Noviyanty, Y., Hepiyansori, & Ardelia, W. (2022). Determination of Total Flavonoid Compounds from The Ethanol Extract of Sweet Arum Mango Fruit Leather with The UV-Vis Spectrophotometry Mthod. Jurnal Sains Kesehatan, 29(1), 1. http://jurnal.stikestrimandirisakti.ac.id/index.php/jsk/article/view/109/pdf DOI: https://doi.org/10.37638/jsk.29.1.1-8
Oladoye, S. O., Falade, V. A., Adepoju, A. J., & Ibikunle, G. J. (2022). Phytochemical Quantification and Efficacy of Persea americana Extracts on Some Selected Pathogens. Majalah Obat Tradisional, 27(2), 153–158. https://doi.org/10.22146/mot.74687 DOI: https://doi.org/10.22146/mot.74687
Pang, Z., Raudonis, R., Glick, B. R., Lin, T. J., & Cheng, Z. (2019). Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnology Advances, 37(1), 177–192. https://doi.org/10.1016/j.biotechadv.2018.11.013 DOI: https://doi.org/10.1016/j.biotechadv.2018.11.013
Pant, D. R., Pant, N. D., Saru, D. B., Yadav, U. N., & Khanal, D. P. (2017). Phytochemical screening and study of antioxidant, antimicrobial, antidiabetic, anti-inflammatory and analgesic activities of extracts from stem wood of Pterocarpus marsupium roxburgh. Journal of Intercultural Ethnopharmacology, 6(2), 170–176. https://doi.org/10.5455/jice.20170403094055 DOI: https://doi.org/10.5455/jice.20170403094055
Pontes, M. H., & Groisman, E. A. (2019). Slow growth dictates non-heritable antibiotic resistance in Salmonella enterica. Sci. Signal, 12(592). https://doi.org/10.1126/scisignal.aax3938.Slow DOI: https://doi.org/10.1126/scisignal.aax3938
Qiu, Y., Zhou, Y., Chang, Y., Liang, X., Zhang, H., Lin, X., Qing, K., Zhou, X., & Luo, Z. (2022). The Effects of Ventilation, Humidity, and Temperature on Bacterial Growth and Bacterial Genera Distribution. International Journal of Environmental Research and Public Health, 19(22). https://doi.org/10.3390/ijerph192215345 DOI: https://doi.org/10.3390/ijerph192215345
Sarker, S. D., Latif, Z., & Gray, A. I. (2006). Natural Products Isolation (2nd ed.). Totowa, Humana Press. DOI: https://doi.org/10.1385/1592599559
Wu, S., Yang, Z., Liu, F., Peng, W., Qu, S., & Li, Q. (2019). Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus. 10(November), 1–14. https://doi.org/10.3389/fmicb.2019.02489 DOI: https://doi.org/10.3389/fmicb.2019.02489
Wulandari, C. (2023). Antibacterial Activity of Hydroalcoholic Extract of Mango Leaf Shoots (Mangifera indica L. var. Arum Manis) against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus [Universitas Wahid Hasyim]. https://eprints.unwahas.ac.id/3277/
Wulandari, & Sulistyarini, I. (2018). Antibacterial activity test of extract ethanol mango arumanis skin ( Mangifera indica L ) on Methicillin Resistant Staphylococcus aureus ( MRSA ). Media Farmasi Indonesia, 13(2), 1347–1353. https://mfi.stifar.ac.id/MFI/article/view/85
