Nanoemulsion Formulation Combination of Virgin Coconut Oil (VCO) and Candlenut Oil (Alleurites mollucanus) for Hair Growth in Male White Rats (Rattus novergicus)

Authors

  • Rindi Ibrahim Lasanudin Student
    Indonesia
  • Mochamad Saiful Bachri Universitas Ahmad Dahlan
    Indonesia
  • Iis Wahyuningsih Universitas Ahmad Dahlan
    Indonesia
  • Nur Ari Efiana Universitas Ahmad Dahlan
    Indonesia

DOI:

https://doi.org/10.23917/pharmacon.v21i1.4348

Keywords:

Candlenut oil, Hair growth , Nanoemulsion, Virgin Coconut Oil

Abstract

Having healthy and thick hair is the dream of many people, but some people have problems related to their hair. Hair problems that often occur are hair loss, thin hair or baldness, so to overcome these problems hair growth products have been made. Virgin Coconut Oil VCO and candlenut oil can be used as natural ingredients that can grow hair. The aim of this research was to determine the best nanoemulsion formulation for a combination of candlenut oil and VCO; and to determine the difference between applying nanoemulsion, conventional candlenut oil, conventional VCO and the oil emulsion on hair growth in male rats. This nanoemulsion formulation uses a combination of candlenut oil and VCO in a ratio of 1:1, 1:3 and 3:1. The nanoemulsion obtained was subjected to organoleptic, pH, viscosity, flow type and % transmittance. The best formulation was then tested for droplet size and zeta potential as well as hair growth activity tests using male rats. It was found that the best nanoemulsion formula was a nanoemulsion with a combination of 1:3 with a yellow color, a distinctive odor and clear with a droplet size of 14.42 ± 0.03 nm, a zeta value of -27.8 ± 1.02 mV, the length of the hair produced in the test hair growth activity was 17.14 ± 0.42 mm and hair weight was 699.37 ± 7.91 mg.

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References

Almas, J. F., Chasanah, U., & Rahmasari, D. (2022). Activity of Hair Tonic Nanoemulsion with Candlenut Oil (Aleurites moluccana) on Mice (Mus musculus). KnE Medicine. https://doi.org/10.18502/kme.v2i3.11917

Blegur, F., & Indrawati, M. I. M. (2015). Test of Pure Coconut Oil or Virgin Coconut Oil (VCO) Activity on the Hair Growth Rate of Male Rabbit's Hair. Jurnal Farmasi_Koe, 1 (1). 45-50.

Boateng, L., Ansong, R., Owusu, W. B., & Steiner-Asiedu, M. (2016). Coconut oil and palm oil’s role in nutrition, health and national development: A review. In Ghana medical journal, Vol. 50, Issue 3, pp. 189–196). https://doi.org/10.4314/gmj.v50i3.11

Chavda, V. P., Patel, A. B., Mistry, K. J., Suthar, S. F., Wu, Z.-X., Chen, Z.-S., & Hou, K. (2022). Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.867655

Chime, S. A., Kenechukwu, F. C., & Attama, A. A. (2014). Nanoemulsions — Advances in Formulation, Characterization and Applications in Drug Delivery. In Application of Nanotechnology in Drug Delivery. InTech. https://doi.org/10.5772/58673

Hamel, A. F., Menard, M. T., & Novak, M. A. (2017). Fatty acid supplements improve hair coat condition in rhesus macaques. Journal of Medical Primatology, 46(5), 248–251. https://doi.org/10.1111/jmp.12271

Handayani, F. S., Nugroho, B. H., & Munawiroh, S. Z. (2018). Optimization of Low-Energy Grape Seed Oil Nanoemulsion Formulation with D-Optimal Mixture Design (DMD). Jurnal Ilmiah Farmasi, 14(1), 17–34. https://doi.org/10.20885/jif.vol14.iss1.art03

Kartika Sari, D., & Wibowo, A. (2016). Herbal Treatment for Hair Loss. Jurnal Majority, 5(5), 129-134.

Kong, W. Y., Salim, N., Masoumi, H. R. F., Basri, M., da Costa, S. S., & Ahmad, N. (2018). Optimization of hydrocortisone-loaded nanoemulsion formulation using D-optimal mixture design. Asian Journal of Chemistry, 30(4), 853–858. https://doi.org/10.14233/ajchem.2018.21104

Le Floc’h, C., Cheniti, A., Connétable, S., Piccardi, N., Vincenzi, C., & Tosti, A. (2015). Effect of a nutritional supplement on hair loss in women. Journal of Cosmetic Dermatology, 14(1), 76–82. https://doi.org/10.1111/jocd.12127

Ludya Pulung, M., Yogaswara, R., Fajar, D., & Sianipar, R. D. N. (2016). Antioxidant and Antibacterial Potential of Virgin Coconut Oil from Papua Native Coconut Plants. Chem. Prog, 9(2). https://doi.org/10.35799/cp.9.2.2016.27991

Mappamasing, F., Anwar, E., & Mun’im, A. (2015). Formulation, Characterization and In Vitro Penetration Study of Resveratrol Solid Lipid Nanoparticles in Topical Cream. Jurnal Ilmu Kefarmasian Indonesia, 13(2), 137–144.

Marlina, Dwi Wijayanti, Ivo Pangesti Yudiastari, Lilis Safitri. (2017). Virgin Coconut Oil Production From Hybrid Coconut Use Salting Method With NaCl And Salt, Jurnal Chemurgy. 01,(2). 10.30872/cmg.v1i2.1139

Nestor, M. S., Ablon, G., Gade, A., Han, H., & Fischer, D. L. (2021). Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. Journal of Cosmetic Dermatology, 20(12), 3759–3781. https://doi.org/10.1111/jocd.14537

Ryu, H. S., Jeong, J., Lee, C. M., Lee, K. S., Lee, J. N., Park, S. M., & Lee, Y. M. (2021). Activation of hair cell growth factors by linoleic acid in malva verticillata seed. Molecules, 26(8). https://doi.org/10.3390/molecules26082117

Senapati, P. C., Sahoo, S. K., & Sahu, A. N. (2016). Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomedicine & Pharmacotherapy, 80, 42–51. https://doi.org/10.1016/j.biopha.2016.02.039

Shah, R., Eldridge, D., Palombo, E., & Harding, I. (2014). Optimisation and Stability Assessment of Solid Lipid Nanoparticles using Particle Size and Zeta Potential. Journal of Physical Science (Vol. 25, Issue 1).

Shoviantari, F., Liziarmezilia, Z., Bahing, A., Agustina, I. (2019). Evaluation of Hair Tonic Activity of Candlenut Oil Nanoemulsion (Aleurites moluccana L.). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 6(2), 69. https://doi.org/10.20473/jfiki.v6i22019.69-73

Son, H.-Y., Lee, M.-S., Chang, E., Kim, S.-Y., Kang, B., Ko, H., Kim, I.-H., Zhong, Q., Jo, Y.-H., Kim, C.-T., & Kim, Y. (2019). Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats. Nutrients, 11(2), 244. https://doi.org/10.3390/nu11020244

Sudjadi, & Rohman, A. (2016). Analysis of pig derivatives. UGM Press.

Sun, J., Feng, X., Lyu, C., Zhou, S., & Liu, Z. (2022). Effects of different processing methods on the lipid composition of hazelnut oil: A lipidomics analysis. Food Science and Human Wellness, 11(2), 427–435. https://doi.org/10.1016/j.fshw.2021.11.024

Yuliani, F., Rohman, A., & Riyanto, S. (2018). Application of FTIR Spectra Combined With Chemometrics For Analysis of Candlenut Oil Adulteration. International Journal of Applied Pharmaceutics. 10 (5). http://dx.doi.org/10.22159/ijap.2018v10i5.28372

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Submitted

2024-02-16

Accepted

2024-06-29

Published

2024-06-30

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Articles