The Influence of Tween 80 in Characteristics and Stability of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of VCO-Nutmeg Seed Oil
DOI:
https://doi.org/10.23917/pharmacon.v23i1.12542Keywords:
Nutmeg Seed Oil, VCO, SNEDDS, Tween 80Abstract
Nutmeg seed oil is hydrophobic and does not penetrate the skin easily. A Self-Nanoemulsifying Drug Delivery System (SNEDDS) produces a nanoemulsion with droplet sizes of 20-200 nm. This improves the stability and skin penetration of nutmeg seed oil. This study aims to investigate the ratios of VCO, Tween 80, and PEG 400 that affect the characteristics and stability of SNEDDS. The Tween 80 ratios in the nutmeg seed oil SNEDDS formulas were F1 (1:4:1), F2 (1:7:1), and F3 (1:8:1). All SNEDDS had an O/W emulsion type. The pH was ≤ 7.5, the % transmittance ranged from 95% to 100%, and viscosity was ≤ 2000 cPa.s with non-Newtonian pseudoplastic rheology. Therefore, particle sizes were 23.71 ± 2.41, 7.4 ± 2.73, and 21.27 ± 0.07 nm. Zeta potentials were 189.3 ± 0.85, 190.0 ± 0.00, and 189.9 ± 0.00 mV, while PDI values were 1.861 ± 1.23, 3.80 ± 1.85, and 0.128 ± 0.09. Among these, F3 showed greater stability and better characteristics than F1 and F2. Increasing Tween 80 concentration improves stability and uniformity, as shown by reduced particle size, higher zeta potential, and more uniform size distribution after testing.
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