Evaluation of the Effectiveness of Banggai Yam (Dioscorea alata L.) Extract Cream for Healing Diabetic Wounds
DOI:
https://doi.org/10.23917/pharmacon.v23i1.12163Keywords:
Diabetes Mellitus, Dioscorea alata L., Rattus norvegicus, Topical cream, Wound healingAbstract
Diabetic wounds are a common complication of diabetes mellitus, typically characterized by impaired or delayed healing. Banggai yam (Dioscorea alata L.) contains bioactive compounds such as flavonoids, saponins, tannins, and phenolics, which possess potential wound-healing properties. This study aimed to evaluate the effectiveness of Banggai yam extract cream on diabetic wound healing in rats. Banggai yam extract was formulated into cream preparations at concentrations of 5%, 10%, and 15% (w/w). Fifteen adult male Wistar rats (Rattus norvegicus) were randomly divided into five groups: a negative control, a positive control, and three treatment groups. Wounds with a diameter of 1 cm were created on the dorsal area and treated twice daily for 12 days. Wound length was measured using a digital caliper and analyzed using One-Way ANOVA. The 15% concentration cream demonstrated the most significant wound-healing activity, achieving a wound closure percentage of 90.00 ± 8.72% by day 12. Statistical analysis showed significant differences among groups (p < 0.05).
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