Identification of Potentially Inappropriate Medication in Geriatric Patients at Wangaya Hospital, Denpasar City with Beers Criteria and Stopp Criteria in 2023

Authors

  • Made Shinta Sanma Putri Sekolah Tinggi Farmasi Mahaganesha
    Indonesia
  • Anak Agung Ngurah Putra Riana Prasetya Program Studi Sarjana Farmasi, Sekolah Tinggi Farmasi Mahaganesha, Denpasar, Indonesia
    Indonesia
  • Putu Dian Marani Kurnianta Program Studi Diploma Tiga Farmasi, Sekolah Tinggi Farmasi Mahaganesha, Denpasar, Indonesia
    Indonesia

Keywords:

Beers Criteria, Geriatrics, PIM, Polypharmacy, STOPP Criteria

Abstract

Geriatric (elderly) patients generally require a number of drugs (polypharmacy) to cure health-related conditions that tend to occur Potentially Inappropriate Medication (PIM). Identification of PIM is very important to prevent Drug Related Problems (DRP).  The purpose of the study was to identify the incidence of PIM using the Beers Criteria and STOPP Criteria and analyze the relationship between PIM risk factors and the incidence of PIM in geriatric patients at Wangaya Hospital, Denpasar City. This type of research is retrospective observational in a cross-sectional manner using simple random sampling techniques on all geriatric patients for the period 2023. Samples that met the inclusion criteria, namely geriatric patients aged ≥65 years in outpatient and inpatient facilities with geriatric patients who died and who were referred to other hospitals, were excluded from this study. Of the 354 samples, the prevalence of PIM in outpatient care was (4.23%) with the most common drugs being spironolactone (55.84%), Sulfonylureas (19.48%), and NSAIDs (6.49%) with Beers criteria. In hospitalization, (0.84%) with NSAIDs (25%), corticosteroids (25%), clopidogrel (25%), and antipsychotics (25%) with STOPP criteria. Based on the evaluation results, there was a very weak correlation between the number of drugs (p=0.000; r=0.199) and there was no relationship between the number of diagnoses (p=0.674) prescribed and the incidence of PIM. Based on this, it can be concluded that the greater the number of diseases and the number of drugs can increase the risk of PIM.

References

AGS. (2023), “American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults”, Journal of the American Geriatrics Society, John Wiley and Sons Inc, Vol. 71 No. 7, pp. 2052–2081, https://doi.org/10.1111/jgs.18372

Al-Azayzih, A., Al-Azzam, S.I., Alzoubi, K.H., Jarab, A.S., Kharaba, Z., Al-Rifai, R.H. and Alnajjar, M.S. (2020), “Nonsteroidal Anti-inflammatory Drugs Utilization Patterns and Risk of Adverse Events due to Drug-Drug Interactions among Elderly Patients: A Study from Jordan”, Saudi Pharmaceutical Journal, Elsevier B.V., Vol. 28 No. 4, pp. 504–508, https://doi.org/10.1016/j.jsps.2020.03.001

Blanco-Reina, E., Valdellós, J., Aguilar-Cano, L., García-Merino, M.R., Ocaña-Riola, R., Ariza-Zafra, G. and Bellido-Estévez, I. (2019), “2015 Beers Criteria and STOPP v2 for detecting potentially inappropriate medication in community-dwelling older people: prevalence, profile, and risk factors”, European Journal of Clinical Pharmacology, Springer Verlag, Vol. 75 No. 10, pp. 1459–1466, https://doi.org/10.1007/s00228-019-02722-0

Cenzer, I., Nkansah-Mahaney, N., Wehner, M., Chren, M.M., Berger, T., Covinsky, K., Berger, K., et al. (2020), “A multiyear cross-sectional study of U.S. national prescribing patterns of first-generation sedating antihistamines in older adults with skin disease”, British Journal of Dermatology, Blackwell Publishing Ltd, Vol. 182 No. 3, pp. 763–769, https://doi.org/10.1111/bjd.18042

Fauziah, H., Mulyana, R. and Martini, R.D. (2020), Polifarmasi Pada Pasien Geriatri, Jurnal Human Care, Vol. 5 No. 3, pp. 804 - 812, https://dx.doi.org/10.32883/hcj.v5i3.796

Filippatos, T.D., Makri, A., Elisaf, M.S. and Liamis, G. (2017), “Hyponatremia in the elderly: Challenges and solutions”, Clinical Interventions in Aging, Dove Medical Press Ltd., 14 November, Vol. 12 No. 1, https://doi.org/10.2147/CIA.S138535

Girouard, C., Grégoire, J.P., Poirier, P. and Moisan, J. (2017), “Effect of contraindicated drugs for heart failure on hospitalization among seniors with heart failure: A nested case-control study”, Medicine (United States), Lippincott Williams and Wilkins, Medicine Journal, Vol. 96 No. 9, https://doi.org/10.1097/MD.0000000000006239

Hibattulwafi, H., Ramadhan, A.M. and Prabowo, W.C. (2022), “Identification of Potentially Inappropriate Drug Prescribing in Geriatric Patients with Cardiovascular Disease Based on STOPP START Criteria at One of The Hospitals in Balikpapan”, Proceeding of Mulawarman Pharmaceuticals Conferences, Faculty of Pharmacy, Mulawarman University, Vol. 15, pp. 77–83, https://doi.org/10.25026/mpc.v15i1.621

Mende, J., Rahmawati, F. and Puspitasari, I. (2022), “Safety of Anticoagulant Use in Ischemic Stroke Hospitalized Patients with Atrial Fibrillation”, Jurnal Manajemen Dan Pelayanan Farmasi (Journal of Management and Pharmacy Practice), Universitas Gadjah Mada, Vol. 12 No. 3, p. 176, https://doi.org/10.22146/jmpf.74893

Misrina, T., Intannia, D., Lingga, H.N., Rahmatullah, S.W. (2023), “Potentially Inappropriate Medications (PIMs) and Potentially Prescribing Omissions (PPOs) on Inpatient Geriatric Patients”, Jurnal Pharmascience 296 Jurnal Pharmascience, Vol. 10 No. 2, pp. 296–309, http://dx.doi.org/10.20527/jps.v10i2.17039.

Mueller, C., John, C., Perera, G., Aarsland, D., Ballard, C. and Stewart, R. (2021), “Antipsychotic use in dementia: the relationship between neuropsychiatric symptom profiles and adverse outcomes”, European Journal of Epidemiology, Springer Science and Business Media B.V., Vol. 36 No. 1, pp. 89–101, https://doi.org/10.1007/s10654-020-00643-2

Namirah M.S.A.A., Darmawan, E. and Mustofa. (2015), “Potentially Inappropriate Medications (Pims) Use Among Elderly Hospitalized Patients with Osteoarthritis at PKU Muhammadiyah Yogyakarta General Hospital”, PharmaCiana, Vol. 5 No. 1, pp. 77–84, http://dx.doi.org/10.12928/pharmaciana.v5i1.2289.

O’Mahony, D., Cherubini, A., Guiteras, A.R., Denkinger, M., Beuscart, J.B., Onder, G., Gudmundsson, A., et al. (2023), “STOPP/START criteria for potentially inappropriate prescribing in older people: version 3”, European Geriatric Medicine, Springer Science and Business Media Deutschland GmbH, Vol. 14 No. 4, pp. 625–632, https://doi.org/10.1007/s41999-023-00777-y

Permenkes. (2014), Peraturan Menteri Kesehatan Republik Indonesia Nomor 75 Tahun 2014, Jakarta.

Sasfi, S.M., Untari, E.K. and Rizkifani, S. (2022), “Evaluation of Prescriptions Pattern in Geriatric Patients at Dr. Soedarso Regional Public Hospital Pontianak Based on Beers Criteria”, Indonesian Journal of Clinical Pharmacy, Vol. 11 No. 2, pp. 95–104, https://doi.org/10.15416/ijcp.2022.11.2.95

Simões, P.A., Santiago, L.M., Maurício, K. and Simões, J.A. (2019), “Prevalence of potentially inappropriate medication in the older adult population within primary care in Portugal: A nationwide cross-sectional study”, Patient Preference and Adherence, Dove Medical Press Ltd., Vol. 13, pp. 1569–1576, https://doi.org/10.2147/PPA.S219346

Tang, J., Wang, K., Yang, K., Jiang, D., Fang, X., Su, S., Lin, Y., et al. (2023), “A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study”, BMC Geriatrics, BioMed Central Ltd, Vol. 23 No. 1, https://doi.org/10.1186/s12877-023-03743-2

Thom, R.P., Mock, C.K. and Teslyar, P. (2017), “Delirium in hospitalized patients: Risks and benefits of antipsychotics”, Cleveland Clinic Journal of Medicine, Cleveland Clinic Educational Foundation, https://doi.org/10.3949/ccjm.84a.16077

Velat, I., Bušić, Ž., Jurić Paić, M. and Čulić, V. (2020), “Furosemide and spironolactone doses and hyponatremia in patients with heart failure”, BMC Pharmacology and Toxicology, BioMed Central, Vol. 21 No. 1, https://doi.org/10.1186/s40360-020-00431-4

Viviandhari, D., Nurhasnah, N., Sakinah, R.N. and Wulandari, D. (2022), “A Comparison of Potentially Inappropriate Medications Identification Using Beers and STOPP Criteria in Hospitalized Geriatric Patients in Jakarta”, Indonesian Journal of Clinical Pharmacy, Indonesian Journal of Clinical Pharmacy, Vol. 11 No. 2, pp. 105–115, https://doi.org/10.15416/ijcp.2022.11.2.105

Wulansari, A., Wiedyaningsih, C. and Probosuseno, P. (2023), “Potentially Inappropriate Medication (PIM) in Geriatric Hospitalized Patient at Dr. H. Moch. Ansari Saleh Regional Public Hospital Banjarmasin”, Majalah Farmaseutik, Universitas Gadjah Mada, Vol. 19 No. 1, p. 91, https://doi.org/10.22146/farmaseutik.v19i1.70420

Zhang, Y., Chen, Z. and Tian, F. (2022), “Potentially inappropriate medications in older Chinese outpatients based on the Beers criteria and Chinese criteria”, Frontiers in Pharmacology, Frontiers Media S.A., Vol. 13, https://doi.org/10.3389/fphar.2022.991087

Submitted

2024-05-30

Accepted

2024-06-29

Published

2024-06-30

Issue

Section

Articles