Antibacterial Activity Test of Gel Toothpaste from Cinnamon Leaf Essential Oil ( Cinnamomum burmanni Blume.) Against Staphylococcus aureus Bacteria
Keywords:
Cinnamon Leaves (Cinnamomum burmanni),, Gel Toothpaste, Antibacterial,, Staphylococcus aureusAbstract
Cinnamon leaf essential oil can inhibit the growth of Staphylococcus aureus bacteria because it contains cinnamaldehyde and eugenol compounds, which function as antibacterials. Staphylococcus aureus is a bacteria involved in various infections in the mouth and human body. This research aims to formulate cinnamon leaf essential oil into a gel toothpaste preparation by differentiating the concentration of cinnamon leaf essential oil as an active ingredient and testing its antibacterial activity against Staphylococcus aureus bacteria. The concentration of active ingredients in formula I is 0.5%, in formula II, 1%, and in formula III, 1.5%. Evaluation of the physical properties of gel toothpaste preparations includes organoleptic, homogeneity, spreadability, pH, viscosity, foam ability, stickiness, and antibacterial activity test against S. aureus using the well diffusion method. The results of the organoleptic and homogeneity evaluations were analyzed descriptively. In contrast, the spreadability, pH, viscosity, foam height, adhesion, stability, and antibacterial activity tests were analyzed
statistically using One-way ANOVA. Organoleptic test results showed yellowish white (FI), light yellow (FII), and yellow (FIII); all three formulas had a characteristic smell of essential oils and were semisolid
and homogeneous. The spreadability test results ranged from 5-5.90 cm, pH value from 5.05-5.47, viscosity value from 31,980-43,900 Cp, foam ability from 9-14 mm and adhesion value from 05.84-08.83 seconds. The antibacterial activity test results for formulas I and II formed an inhibition zone in the strong category, while formula III formed an inhibition zone in the powerful category.
References
Achsia, A. A., Kristijono, A., & Tilarso, D. P. (2021). Aktivitas Anti Candida albicans ATCC 14053
Sediaan Pasta Gigi Gel Ekstrak Daun Jengkol (Archidendron pauciflorum) dengan Kombinasi
Na-CMC dan Karbomer: Activity of Anti-Candida albicans ATCC 14053 Toothpaste Gel Leaf
Extract Jengkol (Archidendron pauciflorum) with Combination of Na-CMC and Carbomer.
Jurnal Sains dan Kesehatan, 3(2), 177–187. https://doi.org/10.25026/jsk.v3i2.267
Amalia, M., Yosuana, P. S., Mohammad, I. S. B., Nababan, F. S. R., Zulkarnain, Wulandari, P., Nasution,
A. H., & Syahputra, A. (2023). Inhibitory test of andaliman (Zanthoxylum achantopodium DC)
extract mouthwash against dental plaque bacteria. Dental Journal (Majalah Kedokteran Gigi),
(2), 92–97. https://doi.org/10.20473/j.djmkg.v56.i2.p92-97
Anggraini, R., Jayuska, A., & Alimuddin, A. H. (2018). Isolasi Dan Karakterisasi Minyak Atsiri Lada
Hitam (Piper nigrum L.) Asal Sajingan Kalimantan Barat. 7(4), 124–133.
Ayuningtyas, N. D., Solichah, A. I., Fadhilah, R. N., & Subekti, T. (2022). Formulasi dan Uji Aktivitas
Antibakteri Nanoemulsi Mouthwash Ekstrak Etanol Daun Jeringau (Acorus calamus Linn.).
Jurnal Sains dan Kesehatan, 4(SE-1), 93–100. https://doi.org/10.25026/jsk.v4iSE-1.1694
Ayuningtyas, N. D., Sudarsono, A. P. P., & Yuswanti, A. S. (2021). Formulation of Toothpaste
Toothpaste Gel Essential Oil of Lime Leaves (Citrus Aurantifolia) With Variations
Concentration of Carbomer 940 As Gelling Agent Base. Jurnal Farmasi & Sains Indonesia, 4(2),
–103. https://doi.org/10.52216/jfsi.vol4no2p98-103
Badan Standardisasi Nasional. (2006). SNI 06-3734-2006 Minyak Kulit Kayu Manis -. Badan
Standardisasi Nasional.
Chumpitazi, B. P., Kearns, G. L., & Shulman, R. J. (2018). Review article: The physiological effects and
safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional
disorders. Alimentary Pharmacology & Therapeutics, 47(6), 738–752.
https://doi.org/10.1111/apt.14519
Dhurhania, C. E. (2019). Penetapan Kadar Metilparaben dan Propilparaben dalam Hand and Body
Lotion secara High Performance Liquid Chromatography. Jurnal Farmasi (Journal of
Pharmacy), 1(1), 38–47. https://doi.org/10.37013/jf.v1i1.12
Egam, A. C. N., Edy, H. J., & Abdullah, S. S. (2023). Formulasi Dan Uji Aktivitas Antibakteri Sediaan
Pasta Gigi Fraksi Etil Asetat Daun Leilem (Clerodendrum minahassae L.) Terhadap Bakteri.
PHARMACON, 12(1), 1–8.
Fernandes, R., Kasuma, N., & Triana, V. (2016). Differences In Effectiveness Toothpaste Gel
Formulation With Paste In Maintaining Normal Salivary PH. Andalas Dental Journal, 4(2), 96–
https://doi.org/10.25077/adj.v4i2.60
Gunawan, H., & Rahayu, Y. P. (2021). Uji Aktivitas Antibakteri Formulasi Sediaan Pasta Gigi Gel
Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp) Terhadap Streptococcus mutans.
Farmasainkes: Jurnal Farmasi, Sains, Dan Kesehatan, 1(1), 56–67.
https://doi.org/10.32696/fjfsk.v1i1.817
Hidayati, N., Mustofa, C. H., & Sugestil, A. (2022). Formulasi dan Uji Sifat Fisis Pasta Gigi Gel Ekstrak
Daun Mangga Bacang (Mangifera foetida Lour.) Dengan Kombinasi Konsentrasi Na CMC dan
Carbomer. CERATA Jurnal Ilmu Farmasi, 13(2), 35–42.
Hudairiah, N. N., Rosalinda, S., & Widyasanti, A. (2021). Formulasi Handbody Lotion (Setil Alkohol
dan Karagenan) dengan Penambahan Ekstrak Delima Merah. Jurnal Teknotan, 15(1), 41.
https://doi.org/10.24198/jt.vol15n1.7
Jailani, A., Sulaeman, R., & Sribudiani, E. (2018). Karakteristik Minyak Atsiri Daun Kayu Manis
(Cinnamomum Burmannii (Ness & Th.Ness)). Jom Faperta UR, 02(02), 493–496.
Pharmacon: Jurnal Farmasi Indonesia, Vol. 21 No. 1 (2024), pp.15-22 22.
https://journals2.ums.ac.id/index.php/pharmacon/
Jesumirhewe, C. & Ayomide Olayinka Ariyo. (2023). Antimicrobial activity of toothpastes and
mouthwashes against oral Staphylococcus aureus isolates. World Journal of Advanced Research
and Reviews, 17(2), 330–335. https://doi.org/10.30574/wjarr.2023.17.2.0176
Khasanah, L. U., Utami, R., Ananditho, B. K., & Nugraheni, A. E. (2014). Pengaruh Perlakuan
Pendahuluan Fermentasi Padat Dan Fermentasi Cair Terhadap Rendemen Dan Karakteristik
Mutu Minyak Atsiri Daun Kayu Manis. AGRITECH, 34(1), 36–42.
Lestari, U., Syamsurizal, S., & Trisna, Y. (2022). The Antiplaque Efficacy and Effectiveness of Activated
Charcoal Toothpaste of Elaeis guineensis in Smokers. Indonesian Journal of Pharmaceutical
Science and Technology, 1, 75–87. https://doi.org/10.24198/ijpst.v1i1.32664
Magvirah, T., Marwati, M., & Ardhani, F. (2020). Uji Daya Hambat BakteriStaphylococcus Aureus
Menggunakan Ekstrak Daun Tahongai (Kleinhovia hospitaL.). Jurnal Peternakan Lingkungan
Tropis, 2(2), Article 2. https://doi.org/10.30872/jpltrop.v2i2.3687
Marlina, D., & Rosalini, N. (2017). Formulasi Pasta Gigi Gel Ekstrak Daun Sukun (Artocarpus altilis)
dengan Natrium CMC Sebagai Gelling Agent dan Uji Kestabilan Fisiknya. Jurnal Kesehatan
Palembang, 12(1), 36–50.
Mayasari, Y., & Kusuma, L. R. I. (2023). Sodium Lauryl Sulfate Toothpaste And Its Relation To Salivary
pH and Plaque Maturation. Cakradonya Dent J, 15(2), 63–71.
Nitasari, I. F., Octaviana, D., Mulyanti, S., & Utami, U. (2022). Gambaran Penurunan Indeks Plak Gigi
Setelah Menggunakan Pasta Gigi Daun Sirih Dan Pasta Gigi Xylitol (Literature Review). Jurnal
Terapi Gigi Dan Mulut, 2(1), 53–60. https://doi.org/10.34011/jtgm.v2i1.1114
Putra, F. S., Mintjelungan, C. N., & Juliatri, . (2017). Efektivitas pasta gigi herbal dan non-herbal
terhadap penurunan plak gigi anak usia 12-14 tahun. e-GIGI, 5(2), 152–158.
https://doi.org/10.35790/eg.5.2.2017.17022
Rini, D. A. P., Almeida, M., & Narsa, A. C. (2022). Sifat Fisika Kimia Tulang Sotong (Sepia Sp.) dan
Optimasi Basis Pasta Gigi: Physicochemical Properties of Cuttlefish Bone (Sepia Sp.) and
Optimization the Toothpaste Base. Proceeding of Mulawarman Pharmaceuticals Conferences,
, 42–47. https://doi.org/10.25026/mpc.v15i1.615
Saputro, A., Astika, Y., & Harismah, K. (2020). Optimasi Sediaan Pasta Gigi Herbal sebagai Antibakteri
dan Sumber Kalsium. Prosiding Seminar Nasional Biologi FMIPA UNM, 71–79.
Suryani, N., Mubarika, D. N., & Komala, I. (2019). Pengembangan dan Evaluasi Stabilitas Formulasi
Gel yang Mengandung Etil p-metoksisinamat. Pharmaceutical and Biomedical Sciences Journal
(PBSJ), 1(1), 29–36. https://doi.org/10.15408/pbsj.v1i1.12688
Utami, R., Khasanah, L. U., Yuniter, K. K., & Manuhara, G. J. (2018). Pengaruh Oleoresin Daun Kayu
Manis (Cinnamomum burmanii) Dua Tahap Terhadap Karakteristik Edible Film Tapioka.
Caraka Tani: Journal of Sustainable Agriculture, 32(1), 55–67.
https://doi.org/10.20961/carakatani.v32i1.15474
Warnida, H., Juliannor, A., & Sukawaty, Y. (2016). Formulasi Pasta Gigi Gel Ekstrak Etanol Bawang
Dayak (Eleutherine bulbosa (Mill.) Urb.). Jurnal Sains Farmasi & Klinis, 03(01), 42–49.
Yauri, L. (2017). Efektifitas Penggunaan Pasta Gigi Dengan Kandungan Xylitol Terhadap Penurunan
Jumlah Plak Pada Murid SDN No. 234 Inpres Takalar Kota Kab. Takalar. Media Kesehatan gigi,
(2), 1–4.