The Role of Physical Activity in Improving Metabolic Syndrome Components: A Literature Review

Authors

  • Nora Eny Zulikha Program Studi Fisioterapi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Surakarta, Indonesia
    Indonesia

DOI:

https://doi.org/10.23917/fisiomu.v7i2.17757

Keywords:

Physical Activity, Metabolic Syndrome, Aerobic Exercise, Resistance Training, Combined Exercise

Abstract

Introduction: Metabolic syndrome represents a worldwide cardiometabolic challenge linked with excess adiposity, insulin insensitivity, type 2 diabetes mellitus, elevated blood pressure, lipid metabolism disorders, and cardiovascular disease. Structured physical activity has been recommended as a non-pharmacological strategy to improve metabolic syndrome components. Methods: This literature review analyzed experimental studies published between January 2021 and April 2026. Articles were searched through PubMed, ScienceDirect, and Google Scholar using the keywords “physical activity,” “exercise,” and “metabolic syndrome” with the Boolean operator “AND.” Research articles were chosen according to specific inclusion and exclusion parameters, subjected to rigorous evaluation utilizing the JBI Critical Appraisal Tool, and synthesized narratively. Eight experimental studies met the eligibility criteria. Results: Physical activity interventions improved waist circumference, body mass index, body weight, blood pressure, lipid profile, cardiorespiratory fitness, fasting glucose, and insulin resistance. Aerobic exercise and the integration of aerobic and resistance training exhibited the most reliable advantages in comparison to interventions that utilized a single modality or were less systematically organized. Conclusion: Structured physical activity is clinically relevant for physiotherapy management of metabolic syndrome. Exercise prescription should prioritize aerobic and combined training with individualized intensity, duration, and progression to optimize cardiometabolic outcomes.

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References

AbouAssi, H., Slentz, C. A., Mikus, C. R., Tanner, C. J., Bateman, L. A., Willis, L. H., Shields, A. T., Piner, L. W., Penry, L. E., Kraus, E. A., Huffman, K. M., Bales, C. W., Houmard, J. A., & Kraus, W. E. (2015). The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from STRRIDE AT/RT: a randomized trial. Journal of Applied Physiology, 118(12), 1474–1482. https://doi.org/10.1152/japplphysiol.00509.2014

Alharbi, H. A., Alsulami, R. Y., Alsuhaibani, R., Muthaffar, A. H., Alsulami, T. M. J., Alzobaidi, A. A. M., Al-Amer, E. S., Alismail, F. B. N., Alnughaymishi, M. K. H., Aldakhil, L. S., & Aldanyowi, S. N. (2024). Assessing the Impact of Digital Programmes and Applications on Patients with Metabolic Syndrome: An Updated Meta-analysis. Journal of Advanced Trends in Medical Research, 1(4), 1147–1158. https://doi.org/10.4103/atmr.atmr_169_24

Chen, X., He, H., Xie, K., Zhang, L., & Cao, C. (2023). Effects of various exercise types on visceral adipose tissue in individuals with overweight and obesity: A systematic review and network meta‐analysis of 84 randomized controlled trials. Obesity Reviews, 25(3). https://doi.org/10.1111/obr.13666

Chomiuk, T., Niezgoda, N., Mamcarz, A., & Śliż, D. (2024). Physical activity in metabolic syndrome. Frontiers in Physiology, 15. https://doi.org/10.3389/fphys.2024.1365761

Das, S., Naina-Mohamed, I., Naina-Mohamed, I., Salim, H. H., Zawawi, A., Thevaraj, T., Ku-Ahmad-Nasir, K. N., Zhou, D. K., & Teoh, S. L. (2021). The Effect of Type, Duration and Intensity of Exercise on Inflammatory Markers CRP, IL-6 and IL-18 in Metabolic Syndrome Patients: A Systematic Review. Sains Malaysiana, 50(7), 1997–2006. Penerbit Universiti Kebangsaan Malaysia. https://doi.org/10.17576/jsm-2021-5007-14

Daud, M. H., Yusoff, F. H., & Ramli, A. S. (2023). The Effect of Mobile Health (mHealth) Interventions on Clinical Outcomes and Self-Management Behaviours in Individuals with Metabolic Syndrome: A Narrative Review of Evidence. Journal of Clinical and Health Sciences, 8(1), 6–33. https://doi.org/10.24191/jchs.v8i1.21452

Ekelund, U., Brage, S., Griffin, S. J., & Wareham, N. J. (2009). Objectively Measured Moderate- and Vigorous-Intensity Physical Activity but Not Sedentary Time Predicts Insulin Resistance in High-Risk Individuals. Diabetes Care, 32(6), 1081–1086. https://doi.org/10.2337/dc08-1895

Griadhi, I. P. A. (2019). ADAPTASI Biomolekuler Hipertropi Jaringan Otot Rangka Pada Latihan Beban Dan Manfaatnya Pada Sindroma Metabolik. Sport and Fitness Journal. https://doi.org/10.24843/spj.2019.v07.i02.p09

Ilanne‐Parikka, P., Laaksonen, D. E., Eriksson, J. G., Lakka, T. A., Lindstr, J., Peltonen, M., Aunola, S., Keinänen‐Kiukaanniemi, S., Uusitupa, M., & Tuomilehto, J. (2010). Leisure-Time Physical Activity and the Metabolic Syndrome in the Finnish Diabetes Prevention Study. Diabetes Care, 33(7), 1610–1617. https://doi.org/10.2337/dc09-2155

Ismail, I. F., Keating, S. E., Baker, M. K., & Johnson, N. A. (2011). A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obesity Reviews, 13(1), 68–91. https://doi.org/10.1111/j.1467-789x.2011.00931.x

Jannah, I. N. S. M., Buntoro, I. F., Folamauk, C. L. H., & Kareri, D. G. R. (2023). Hubungan Aktivitas Fisik Terhadap Kejadian Sindrom Metabolik Pada Civitas Akademika Universitas Nusa Cendana. Cendana Medical Journal, 11(2), 237–246. https://doi.org/10.35508/cmj.v11i2.13901

Jastrzębska, M., Żebrowska, A., & Stańczyk, J. (2023). Effect of Exercise Interventions on Irisin and Interleukin-6 Concentrations and Indicators of Carbohydrate Metabolism in Males with Metabolic Syndrome. Journal of Clinical Medicine.

Kassi, E., Pervanidou, P., Kaltsas, G., & Chrousos, G. P. (2011). Metabolic syndrome: definitions and controversies [Review of Metabolic syndrome: definitions and controversies]. BMC Medicine, 9(1). BioMed Central. https://doi.org/10.1186/1741-7015-9-48

Korn, P. von, Keating, S. E., Mueller, S., Haller, B., Kraenkel, N., Dinges, S., Duvinage, A., Scherr, J., Wisløff, U., Tjønna, A. E., Halle, M., & Lechner, K. (2020). The Effect of Exercise Intensity and Volume on Metabolic Phenotype in Patients with Metabolic Syndrome: A Randomized Controlled Trial. Metabolic Syndrome and Related Disorders, 19(2), 107–114. https://doi.org/10.1089/met.2020.0105

Laaksonen, D. E., Lakka, H., Salonen, J. T., Niskanen, L., Rauramaa, R., & Lakka, T. A. (2002). Low Levels of Leisure-Time Physical Activity and Cardiorespiratory Fitness Predict Development of the Metabolic Syndrome. Diabetes Care, 25(9), 1612–1618. https://doi.org/10.2337/diacare.25.9.1612

Liang, M., Pan, Y., Zhong, T., Zeng, Y., & Cheng, A. S. K. (2021). Effects of aerobic, resistance, and combined exercise on metabolic syndrome parameters and cardiovascular risk factors: a systematic review and network meta-analysis. Reviews in Cardiovascular Medicine, 22(4), 1523–1533. https://doi.org/10.31083/j.rcm2204156

Lorenzo, C., Serrano‐Ríos, M., Martin, N. G., González‐Sánchez, J. L., Seclén, S., Villena, A., González‐Villalpando, C., Williams, K., & Haffner, S. M. (2006). Geographic Variations of the International Diabetes Federation and the National Cholesterol Education Program–Adult Treatment Panel III Definitions of the Metabolic Syndrome in Nondiabetic Subjects. Diabetes Care, 29(3), 685–691. https://doi.org/10.2337/diacare.29.03.06.dc05-1796

Mascaró, C. M., Bouzas, C., Montemayor, S., Casares, M., Llompart, I., Ugarriza, L., Borràs, P. A., Martínéz, J. A., & Tur, J. A. (2022). Effect of a Six-Month Lifestyle Intervention on the Physical Activity and Fitness Status of Adults with NAFLD and Metabolic Syndrome. Nutrients, 14(9), 1813–1813. https://doi.org/10.3390/nu14091813

Meryska, R., Khotimah, S., & Wulandari, R. (2025). Differences in the Effect of Aerobic Exercise and Resistance Exercise on Cardiovascular Endurance in Metabolic Syndrome. FISIO MU Physiotherapy Evidences, 6(2), 143–151. https://doi.org/10.23917/fisiomu.v6i2.8893

Morales‐Palomo, F., Moreno‐Cabañas, A., Álvarez-Jiménez, L., Mora‐Gonzalez, D., Ortega, J. F., & Mora‐Rodríguez, R. (2023). Efficacy of morning versus afternoon aerobic exercise training on reducing metabolic syndrome components: A randomized controlled trial. The Journal of Physiology, 602(23), 6463–6477. https://doi.org/10.1113/jp285366

Mulyani, N. S., Fitriyaningsih, E., Wagustina, S., & Arnisam, A. (2023). Deteksi dini kejadian sindrom metabolik melalui penyuluhan gizi, pengukuran Indeks Massa Tubuh (IMT) dan pemeriksaan tekanan darah serta kadar gula darah. Jurnal PADE Pengabdian & Edukasi, 5(1), 34–34. https://doi.org/10.30867/pade.v5i1.1098

Myers, J., Kokkinos, P., & Nyelin, E. (2019). Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome. Nutrients, 11(7), 1652–1652. https://doi.org/10.3390/nu11071652

Niu, M., Chen, J., Hou, R., Sun, Y., Xiao, Q., Pan, X., & Zhu, X. (2023). Emerging healthy lifestyle factors and all-cause mortality among people with metabolic syndrome and metabolic syndrome-like characteristics in NHANES. Journal of Translational Medicine, 21(1). https://doi.org/10.1186/s12967-023-04062-1

Noubiap, J. J., Nansseu, J. R., Nyaga, U. F., et al. (2026). Worldwide trends in metabolic syndrome from 2000 to 2023: A systematic review and modelling analysis. Nature Communications, 17, 573. https://doi.org/10.1038/s41467-025-67268-5

Ostman, C., Smart, N. A., Morcos, D., Duller, A., Ridley, W. E., & Jewiss, D. (2017). The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis. Cardiovascular Diabetology, 16(1). BioMed Central. https://doi.org/10.1186/s12933-017-0590-y

Pattyn, N., Cornelissen, V., Eshghi, S. R. T., & Vanhees, L. (2012). The Effect of Exercise on the Cardiovascular Risk Factors Constituting the Metabolic Syndrome. Sports Medicine, 43(2), 121–133. Springer Science+Business Media. https://doi.org/10.1007/s40279-012-0003-z

Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012). Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training. Comprehensive Physiology, 1–58. Wiley. https://doi.org/10.1002/cphy.c110062

Ruiz, J. R., Sevilla‐Lorente, R., & Amaro‐Gahete, F. J. (2023). Time for precision exercise prescription: the same timing may not fit all. The Journal of Physiology, 602(23), 6479–6480. https://doi.org/10.1113/jp285958

Saely, C. H., Koch, L., Schmid, F., Marte, T., Aczél, S., Langer, P., Hoefle, G., & Drexel, H. (2006). Adult Treatment Panel III 2001 but Not International Diabetes Federation 2005 Criteria of the Metabolic Syndrome Predict Clinical Cardiovascular Events in Subjects Who Underwent Coronary Angiography. Diabetes Care, 29(4), 901–907. https://doi.org/10.2337/diacare.29.04.06.dc05-2011

Saklayen, M. G. (2018). The Global Epidemic of the Metabolic Syndrome. Current Hypertension Reports, 20(2). Springer Science+Business Media. https://doi.org/10.1007/s11906-018-0812-z

Sequí‐Domínguez, I., Álvarez‐Bueno, C., Martínez‐Vizcaíno, V., Fernández-Rodríguez, R., Saz‐Lara, A., & Cavero‐Redondo, I. (2020). Effectiveness of Mobile Health Interventions Promoting Physical Activity and Lifestyle Interventions to Reduce Cardiovascular Risk Among Individuals With Metabolic Syndrome: Systematic Review and Meta-Analysis. Journal of Medical Internet Research, 22(8). JMIR Publications. https://doi.org/10.2196/17790

Silva, F. M., Duarte‐Mendes, P., Teixeira, A., Soares, C., & Ferreira, J. P. (2024). The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis [Review of The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis]. Scientific Reports, 14(1). Nature Portfolio. https://doi.org/10.1038/s41598-024-51832-y

Szczepanowski, R., Pasiak, K., & Zieliński, J. (2023). Exercise-Induced Alternations of Adiponectin, Interleukin-8 and Indicators of Carbohydrate Metabolism in Males with Metabolic Syndrome. Biomolecules.

Thabet, T. H., ELdeeb, A. M., Osman, D. A., Kamel, H. E. H., Kentiba, E., & Abbas, M. A. M. (2026). Effect of Pilates Exercise versus Aerobic Exercise on Metabolic Syndrome in Pre-menopausal Women. Health Sport Rehabilitation. https://doi.org/10.58962/hsr.1356

Valdés, C. C., Sánchez, L. H. R., Herrera-Ponce, A., & Candeaux, L. E. (2025). Virtual therapeutic exercise system for the treatment of metabolic syndrome. Revista de Ciencia y Tecnología, 43, 111–118. https://doi.org/10.36995/j.recyt.2025.43.009

Vari, I. S., Balkau, B., Kettaneh, A., André, P., Tichet, J., Fumeron, F., Cacès, E., Marre, M., Grandchamp, B., & Ducimetière, P. (2007). Ferritin and Transferrin Are Associated With Metabolic Syndrome Abnormalities and Their Change Over Time in a General Population. Diabetes Care, 30(7), 1795–1801. https://doi.org/10.2337/dc06-2312

Wong, E. M. L., Leung, D. Y. P., Tam, H. L., Wang, Q., Yeung, S. K. W., & Leung, A. Y. M. (2021). The Effect of a Lifestyle Intervention Program Using a Mobile Application for Adults with Metabolic Syndrome, versus the Effect of a Program Using a Booklet: A Pilot Randomized Controlled Trial. Clinical Interventions in Aging, 633–644. https://doi.org/10.2147/cia.s303920

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Submitted

2026-05-25

Accepted

2026-05-29

Published

2026-06-01

How to Cite

Zulikha, N. E. (2026). The Role of Physical Activity in Improving Metabolic Syndrome Components: A Literature Review. FISIO MU: Physiotherapy Evidences, 7(2), 70–88. https://doi.org/10.23917/fisiomu.v7i2.17757